CUB-Domain-Containing Protein 1 Regulates Peritoneal Dissemination of Gastric Scirrhous Carcinoma
نویسندگان
چکیده
منابع مشابه
Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination.
The function of CUB domain-containing protein 1 (CDCP1), a recently described transmembrane protein expressed on the surface of hematopoietic stem cells and normal and malignant cells of different tissue origin, is not well defined. The contribution of CDCP1 to tumor metastasis was analyzed by using HeLa carcinoma cells overexpressing CDCP1 (HeLa-CDCP1) and a high-disseminating variant of prost...
متن کاملICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma.
PURPOSE Human scirrhous gastric carcinoma develops peritoneal dissemination with high frequency, and the prognosis of patients with peritoneal metastasis is poor. There have been few reports of an immunogene therapy for peritoneal dissemination. Intercellular adhesion molecule (ICAM)-2 is a second ligand of leukocyte function-associated antigen-1, which functions as a costimulatory molecule for...
متن کاملIntraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma.
Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). A...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology CDCP 1 ( CUB domain containing protein 1 )
Review on CDCP1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
متن کاملStudy of stroma in scirrhous gastric carcinoma.
Rabbits were immunized with the supernatant of a homogenate of non-cancerous gastric mucosa to obtain an antiserum. This antiserum, after absorption by human jejunal mucosa and liver tissue, produced precipitin lines with the supernatants of homogenates of gastric carcinoma and gastric mucosa. Fluorescent staining was attempted using this antiserum. Well-stained cytoplasms were observed in cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2008
ISSN: 0002-9440
DOI: 10.2353/ajpath.2008.070981